PROPHYLACTIC MEDICATIONS FOR ALLERGIC NOSES: CROMOLYN SODIUM NASAL SPRAY

Cromolyn sodium, manufactured by Fisons Corporation and available in the United States as Nasalcrom Nasal Solution since the early 1970s, was the first allergy prophylactic medication developed and marketed worldwide. A prophylactic medication is defined as one that acts as a preventative against disease. Cromolyn sodium functions as a prophylactic medication because it prevents the allergic process from developing. No process, no symptoms. This is in contrast to the other medications for allergic rhinitis-antihistamines, decongestants, corticosteroids, and ipratropium bromide – which act to relieve the symptoms, caused by the allergic process, but do not alter the process itself.
Since the early ’70s, much has been learned about this remarkable medication. Its list of actions currently includes the following:
- Preventing the release of mediators from mast cells
- Preventing the accumulation of inflammatory cells in the lining of the nose
- Blocking both early and late allergic reactions
- Inhibiting the action of cells that cause inflammation
It is the chemical mediators released during allergic reactions that cause the persistent inflammation characteristic of chronic rhinitis. Because of its ability to prevent the release of these chemicals into the nasal tissue, cromolyn sodium is widely prescribed by physicians as an allergy “blocking” drug. Of note is that cromolyn sodium is not an antihistamine, a decongestant, or a steroid.
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PROPHYLACTIC MEDICATIONS FOR ALLERGIC NOSES: CROMOLYN SODIUM NASAL SPRAYCromolyn sodium, manufactured by Fisons Corporation and available in the United States as Nasalcrom Nasal Solution since the early 1970s, was the first allergy prophylactic medication developed and marketed worldwide. A prophylactic medication is defined as one that acts as a preventative against disease. Cromolyn sodium functions as a prophylactic medication because it prevents the allergic process from developing. No process, no symptoms. This is in contrast to the other medications for allergic rhinitis-antihistamines, decongestants, corticosteroids, and ipratropium bromide – which act to relieve the symptoms, caused by the allergic process, but do not alter the process itself.Since the early ’70s, much has been learned about this remarkable medication. Its list of actions currently includes the following:- Preventing the release of mediators from mast cells- Preventing the accumulation of inflammatory cells in the lining of the nose- Blocking both early and late allergic reactions- Inhibiting the action of cells that cause inflammationIt is the chemical mediators released during allergic reactions that cause the persistent inflammation characteristic of chronic rhinitis. Because of its ability to prevent the release of these chemicals into the nasal tissue, cromolyn sodium is widely prescribed by physicians as an allergy “blocking” drug. Of note is that cromolyn sodium is not an antihistamine, a decongestant, or a steroid.*49/322/5*

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