It is useful to combine an analgesic with a medication which prevents nausea. Although there are many drugs acting against nausea, only one, metaclopramide (Maxolon), also has a specific action on the motility of the stomach, making it empty faster so that tablets or medicine will be passed into the small intestine and absorbed more quickly. This has been shown by measuring the levels of aspirin in the blood stream, which are twice as high after metaclopramide is given during the acute migraine attack. It should be given 15 minutes before other drugs to help absorption. Prochlorperazine (Stemetil) has a more powerful anti-nausea effect but does not affect the motility of the stomach. These anti-emetics are more effective when given by injection but this is not practicable in the home. Unfortunately the tablets may not be absorbed and metaclopramide is not available in suppository form. Some people prefer taking these medicines in the form of a syrup.
Perhaps the most effective popular remedy for migraine is a combination of an anti-emetic, paracetamol, caffeine and codeine known as Migraleve. This can be useful in the mild attack but is not quickly absorbed with more severe attacks.
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